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PRAŽSKÝ POHÁR - BANK

26.2.19 | Jakub Čmiko Přečteno: 967×

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What is Arimidex?

For the treatment of breast cancer, a new drug, Arimidex, has been developed, which is superior to tamoxifen. Arimidex, one of three new drugs belonging to the class of aromatase inhibitors, suppresses the synthesis of female sex hormones estrogen in the early stages. Thus, the drug prevents the recurrence of typical tumors for the postmenopausal period in 70-80% of patients compared with tamoxifen (50%). The use of the drug for 5 years after surgery significantly reduces the likelihood of metastasis and recurrence. This conclusion was made on the basis of a study with the inclusion of 2,000 American patients and 7,300 patients from other countries. After the removal of breast cancer, the use of Arimidex for 2 years was found to be more effective than treatment with tamoxifen for 5 years. However, if breast cancer appeared before menopause, then tamoxifen is much more effective than new drugs. Tamoxifen blocks the effect of estrogen, an excess of which in postmenopause causes 75% of breast cancers. In patients with hormone-dependent breast tumors, Arimidex, compared with tamoxifen, increases 5-year survival by 17%. Moreover, the earlier treatment is started, the more effective it is. The drug is less likely than tamoxifen, leads to uterine cancer, thrombosis, vaginal bleeding, flushing, but more often causes pain in muscles and joints, osteoporosis. On average, the risk of breast cancer recurrence is 40% lower with Arimidex than with tamoxifen treatment.

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